Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development
نویسندگان
چکیده
منابع مشابه
Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development.
The function of the adult thyroid is regulated by thyroid-stimulating hormone (TSH), which acts through a G protein-coupled receptor. Overactivation of the TSH receptor results in hyperthyroidism and goiter. The Gs-mediated stimulation of adenylyl cyclase-dependent cAMP formation has been regarded as the principal intracellular signaling mechanism mediating the action of TSH. Here we show that ...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2007
ISSN: 0021-9738
DOI: 10.1172/jci30380